Investigation On Structure And Anticonvulsant Activity Of Transition Metal Complexes Derived From ‘End-Off’ Compartmental N,N’-bis-(isatin hydrazone)-2,6-Pyridinedicarboxamide

Sathisha M.P.¹*, Prashanth S. Adarakatti²*, Ashish Anand³

¹Department of Chemistry, KLE’s RLS Institute, Belagavi – 590001, (INDIA)
²Department of Chemistry, SVM Arts, Science & Commerce College, Ilkal – 587125, (INDIA)
³Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru – 560012, (INDIA)

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ABSTRACT – DOI: https://dx.doi.org/10.47204/ACI.1.1.2021.43-54

The isatin scaffold is an important pharmacophores responsible for anticonvulsant activity was anchored with pyridinedicarboxamide via amide linkage producing a potential ligand N,N- bis(isatin hydrazone) pyridine 2,6-dicarboxamide (LH₂). The Co(II), Ni(II), Cu(II) and Zn(II) complex of this ligand were synthesized and characterized. The bonding and stereochemistry of the synthesized compounds have been characterized by IR, ¹HNMR, UV-Vis, mass spectrometry and magnetic moment data. The isatin linked amide ligand behaves as ‘end-off’ compartmental O,N,N,N,O multidentate scaffold through the two uncharged amide nitrogen, pyridine nitrogen, and two amide oxygen of isatin via deprotonation. The ligand LH₂ and [Ni(C₂₃H₁₇N₇O₄)H₂O], [Cu(C₂₃H₁₇N₇O₄)H₂O] complexes appear to suppress the maximal electroshock and act as a better anticonvulsants.