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Govt. of India Trust : E/11049/Rajkot
Income tax of India 80G : AADTK8161HF20221
Income tax of India 12A : AADTK8161HE20217

Volume 1 – Issue 1 – 2021

Original Research Article

Investigation On Structure And Anticonvulsant Activity Of Transition Metal Complexes Derived From ‘End-Off’ Compartmental N,N’-bis-(isatin hydrazone)-2,6-Pyridinedicarboxamide

Sathisha M.P.1*, Prashanth S. Adarakatti2*, Ashish Anand3

1Department of Chemistry, KLE’s RLS Institute, Belagavi – 590001, (INDIA)
2Department of Chemistry, SVM Arts, Science & Commerce College, Ilkal – 587125, (INDIA)
3Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru – 560012, (INDIA)

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The isatin scaffold is an important pharmacophores responsible for anticonvulsant activity was anchored with pyridinedicarboxamide via amide linkage producing a potential ligand N,N- bis(isatin hydrazone) pyridine 2,6-dicarboxamide (LH2). The Co(II), Ni(II), Cu(II) and Zn(II) complex of this ligand were synthesized and characterized. The bonding and stereochemistry of the synthesized compounds have been characterized by IR, 1HNMR, UV-Vis, mass spectrometry and magnetic moment data. The isatin linked amide ligand behaves as ‘end-off’ compartmental O,N,N,N,O multidentate scaffold through the two uncharged amide nitrogen, pyridine nitrogen, and two amide oxygen of isatin via deprotonation. The ligand LH2 and [Ni(C23H17N7O4)H2O], [Cu(C23H17N7O4)H2O] complexes appear to suppress the maximal electroshock and act as a better anticonvulsants.