Registration Details    
Govt. of India Trust : E/11049/Rajkot
Income tax of India 80G : AADTK8161HF20221
Income tax of India 12A : AADTK8161HE20217

Volume 1 – Issue 2 – 2021

Original Research Article

Generation Of Radio Nuclides [64Cu, 62Cu, 18F, 11C] Through The Giant Dipole Mechanism

Yogendra Srivastava1*, John Swain2, Allan Widom2, Georges de Montmollin3, Pierre-Alain Tercier4, Olivier Pisaturo4, Frederic Mieville4

1Department of Physics and Geology, University of Perugia, Perugia, (ITALY)
2Physics Department, Northeastern University, Boston MA, (USA)
3Lenr-Cities Suisse Sárl, Neuchatel, (SWITZERLAND)
4Radiation Oncology Department, hôpital fribourgeois, CH-1708, Fribourg, (SWITZERLAND)

PAGE NO: 120-132


We describe the generation of radio nuclides -needed for imaging and treatment in nuclear medicine- through the giant dipole mechanism and electro-strong interactions. Electron accelerators routinely available in radiation oncology departments when suitably modified can be used for this purpose. The method is applied to the particularly important case of (i) Copper radio nuclides (RI) [62Cu, 64Cu] that are of interest both for imaging and cancer treatment, as well as (ii) for the production of the imaging RI 18F and 11C together. Experimental data that show the feasibility of the scheme are presented here through the production of radio nuclides [62Cu & 64Cu] when a sample of pure Copper was irradiated by a beam of 22 MeV electrons accelerator facility in the radiation oncology department of the Swiss Fribourg hospital. Firm evidence of RI production is provided through the measurements of the radiation from the two Copper RI and the two measured life-times are within 2% of their expected values. Also presented -to our knowledge for the first time- are experimental results about the production of the much sought after RI 18F along with another 11C in one shot, through a non-cyclotron or a nuclear reactor source. Our results confirm the hypothesis that upon suitable modifications, electron accelerators available at medical radiation oncology centers, can indeed be used to produce the required amounts of radio nuclei in situ locally, when needed. It should reduce the cost of production as well as that of transport and at the same time avoid the use of nuclear reactors [or cyclotrons] that (may) suffer from the production of unwanted nuclear waste. For the future, a scaled up RI production through high intensity electron machines can allow us to develop a novel strategy: pinpoint a tumor through an RI with a chelated material accompanying it to fight the tumor -in real time- with less cumbersome biological assays.