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Volume 3 РIssue 1 Р2022

Original Research Article

Novel Metal Complexes As Potential Chemotherapeutic Agents

Abdou S. El-Tabl1*, Moshira M. Abd-El Wahed2, Al-Zahraa Ibrahim El-Mahsarawy1,
Mohamed Samy Abd El-Khalek1, Sameh Anwer Zwam1

1Department of Chemistry, Faculty of Science, El-Menoufia University, Shebin El-Kom, (EGYPT)
2Department of Pathology, Faculty of Medicine, El-Menoufia University, Shebin El-Kom, (EGYPT)

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ABSTRACT –¬†DOI: https://dx.doi.org/10.47204/EMSR.3.1.2021.019-038

A new series of Na(I), Ag(I), Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Pb(II), Cr(III) and Fe(III) complexes of 4,6-bis((1E)-1-((2-((furan-2-ylmethylene)amino)ethyl)imino)ethyl)benzene-1,3-diol had been prepared. The ligand and its metal complexes had been characterized using 1H-NMR, Mass spectra, IR, UV-VIS and ESR spectra, Magnetic moments, Conductance measurements, as well as Elemental and Thermal analyses (DTA and TGA). Molar conductance in DMF solution indicated that, the complexes were non-electrolytes. The electronic spectral data and elemental analysis showed that, all complexes had distorted octahedral structure around the metal ions. The ESR spectra of solid complexes (2) [(L)(Cu)2(OAc)2(H2O)4].3H2O, (3) [(H2L) (Cu)2(SO4) (H2O)4].2H2O and (4) [(L)(Cu)2(Cl)2(H2O)4].H2O showed axial type symmetry d(x2-y2) ground state with considerable covalent bond character. However, the other complexes showed isotropic type. Chemotherapeutic activity of the ligand and some of its complexes was studied. The results showed that, some complexes recorded high cytotoxicity against HEPG-2 cell lines regarding to IC50. Also, the cytotoxicity was found to be concentration dependent.